منابع مشابه
Oncogenic Phenotypes in K-Ras Transformed Cells
Genetic mutations in K-Ras, an oncogene belonging to the Ras protein superfamily, are present in number of cancers, including over 90% of pancreatic and 50% of colorectal cancers. The mutated or oncogenic form of the K-Ras GTPase is perpetually locked in the GTP-bound active conformation, thereby inducing extreme and rapid cell proliferation as well as decreasing cell sensitivity to suspension-...
متن کاملAcute sensitivity of the oral mucosa to oncogenic K-ras
Mouse models of cancer represent powerful tools for analysing the role of genetic alterations in carcinogenesis. Using a mouse model that allows tamoxifen-inducible somatic activation (by Cre-mediated recombination) of oncogenic K-ras(G12D) in a wide range of tissues, we observed hyperplasia of squamous epithelium located in moist or frequently abraded mucosa, with the most dramatic effects in ...
متن کاملYAP1 Takes Over when Oncogenic K-Ras Slumbers
It is of great therapeutic importance to understand why tumors relapse after the failure of therapies targeting oncogenes to which cancer cells are addicted. In this issue, Kapoor et al. and Shao et al. identify the transcriptional coactivator YAP1 as a central driver of compensation for the loss of K-Ras signaling in K-Ras-dependent cancers.
متن کاملNf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice.
Hyperactive RAS signaling is caused by mutations in RAS genes or a deficiency of the neurofibromatosis gene (NF1) and is common in myeloid malignancies. In mice, expression of oncogenic K-RAS or inactivation of Nf1 in hematopoietic cells results in myeloproliferative disorders (MPDs) that do not progress to acute myeloid leukemia (AML). Because NF1 is a RAS-GTPase-activating protein it has been...
متن کاملOncogenic K-ras cooperates with PML-RAR to induce an acute promyelocytic leukemia–like disease
Most patients with acute promyelocytic leukemia (APL) express PML-RAR , the fusion product of t(15;17)(q22;q11.2). Transgenic mice expressing PML-RAR develop APL with long latency, low penetrance, and acquired cytogenetic abnormalities. Based on observations that 4% to 10% of APL patients harbor oncogenic ras mutations, we coexpressed oncogenic K-ras from its endogenous promoter with PML-RAR to...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2019
ISSN: 2154-1248,2154-1256
DOI: 10.1080/21541248.2019.1655883